Biotin—(methylcrotonoyl-CoA-carboxylase) ligase
| biotin-[methylcrotonoyl-CoA-carboxylase] ligase | |||||||
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| Identifiers | |||||||
| EC number | 6.3.4.11 | ||||||
| CAS number | 37318-68-6 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, a biotin-[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11) is an enzyme that catalyzes the chemical reaction
- ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
The 3 substrates of this enzyme are ATP, biotin, and [[apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]]], whereas its 3 products are AMP, diphosphate, and 3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming).
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include biotin-[methylcrotonoyl-CoA-carboxylase] synthetase, biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase, beta-methylcrotonyl coenzyme A holocarboxylase synthetase, and holocarboxylase-synthetase. This enzyme participates in biotin metabolism.